The relationship between local scalp skin temperature and cutaneous perfusion during scalp cooling

Cooling the scalp during administration of chemotherapy can prevent hair loss. It reduces both skin blood flow and hair follicle temperature, thus affecting drug supply and drug effect in the hair follicle. The extent to which these mechanisms contribute to the hair preservative effect of scalp cooling remains unknown. The purpose of this study was to establish a relationship between local scalp skin temperature and cutaneous blood flow during scalp cooling. We measured skin temperature and cutaneous perfusion during a cooling and re-warming experiment. Experiments on a single subject showed that the measurements were reproducible and that the response was identical for the two positions that were measured. Inter-subject variability was investigated on nine subjects. We found that for the first 10 °C of cooling, perfusion of the scalp skin decreases to below 40%. Perfusion can be further reduced to below 30% by a few degrees more cooling, but a plateau is reached after that. We found that a generally accepted relation in thermal physiology between temperature and perfusion (i.e. Q10 relation) does not describe the data well, but we found an alternative relation that describes the average behavior significantly better

Complementarity of the Maldacena and Karch-Randall Pictures

We perform a one-loop test of the holographic interpretation of the Karch-Randall model, whereby a massive graviton appears on an AdS_4 brane in an AdS_5 bulk. Within the AdS/CFT framework, we examine the quantum corrections to the graviton propagator on the brane, and demonstrate that they induce a graviton mass in exact agreement with the Karch-Randall result. Interestingly enough, at one loop order, the spin 0, spin 1/2 and spin 1 loops contribute to the dynamically generated (mass)^2 in the same 1: 3: 12 ratio as enters the Weyl anomaly and the 1/r^3 corrections to the Newtonian gravitational potential.Comment: 20 pages, Revtex 3, Discussion on the absence of a scalar ghost clarified; Additional details on the computation give

Effect of Anesthesia on Microelectrode Recordings During Deep Brain Stimulation Surgery:A Narrative Review

Deep brain stimulation (DBS) is an effective surgical treatment for patients with various neurological and psychiatric disorders. Clinical improvements rely on careful patient selection and accurate electrode placement. A common method for target localization is intraoperative microelectrode recording (MER). To facilitate MER, DBS surgery is traditionally performed under local or regional anesthesia. However, sedation or general anesthesia is sometimes needed for patients who are unable to tolerate the procedure fully awake because of severe motor symptoms, psychological distress, pain, or other forms of discomfort. The effect of anesthetic drugs on MER is controversial but likely depends on the type and dose of a particular anesthetic agent, underlying disease, and surgical target. In this narrative review, we provide an overview of the current literature on the anesthetic drugs most often used for sedation and anesthesia during DBS surgery, with a focus on their effects on MERs

Analysis of coelom development in the sea urchin Holopneustes purpurescens yielding a deuterostome body plan

Companion Research Data "Two Z stacks of coelomogenesis in vestibula larvae of the sea urchin Holopneustes purpurescens recorded by high resolution confocal laser scanning microscopy from Morris (2016)" at http://hdl.handle.net/2123/14227An analysis of early coelom development in the echinoid Holopneustes purpurescens yields a deuterostome body plan that explains the disparity between the pentameral plan of echinoderms and the bilateral plans of chordates and hemichordates, the three major phyla of the monophyletic deuterostomes. The analysis shows an early separation into a medial hydrocoele and lateral coelomic mesoderm with an enteric channel between them before the hydrocoele forms the pentameral plan of five primary podia. The deuterostome body plan thus has a single axial or medial coelom and a pair of lateral coeloms, all surrounding an enteric channel, the gut channel. Applied to the phyla, the medial coelom is the hydrocoele in echinoderms, the notochord in chordates and the proboscis coelom in hemichordates: the lateral coeloms are the coelomic mesoderm in echinoderms, the paraxial mesoderm in chordates and the lateral coeloms in hemichordates. The plan fits frog and chick development and the echinoderm fossil record, and predicts genes involved in coelomogenesis as the source of deuterostome macroevolution

Multifractality at the spin quantum Hall transition

Statistical properties of critical wave functions at the spin quantum Hall transition are studied both numerically and analytically (via mapping onto the classical percolation). It is shown that the index $\eta$ characterizing the decay of wave function correlations is equal to 1/4, at variance with the $r^{-1/2}$ decay of the diffusion propagator. The multifractality spectra of eigenfunctions and of two-point conductances are found to be close-to-parabolic, $\Delta_q\simeq q(1-q)/8$ and $X_q\simeq q(3-q)/4$.Comment: 4 pages, 3 figure

Intersecting D-Branes in ten and six dimensions

We show how, via $T$-duality, intersecting $D$-Brane configurations in ten (six) dimensions can be obtained from the elementary $D$-Brane configurations by embedding a Type IIB $D$-Brane into a Type IIB Nine-Brane (Five-Brane) and give a classification of such configurations. We show that only a very specific subclass of these configurations can be realized as (supersymmetric) solutions to the equations of motion of IIA/IIB supergravity. Whereas the elementary $D$-brane solutions in $d=10$ are characterized by a single harmonic function, those in $d=6$ contain two independent harmonic functions and may be viewed as the intersection of two $d=10$ elementary $D$-branes. Using string/string/string triality in six dimensions we show that the heterotic version of the elementary $d=6$ $D$-Brane solutions correspond in ten dimensions to intersecting Neveu-Schwarz/Neveu-Schwarz (NS/NS) strings or five-branes and their $T$-duals. We comment on the implications of our results in other than ten and six dimensions.Comment: 18 pages, Latex, (substantial changes in section 2

Potential benefits of an adaptive forward collision warning system

Forward collision warning (FCW) systems can reduce rear-end vehicle collisions. However, if the presentation of warnings is perceived as mistimed, trust in the system is diminished and drivers become less likely to respond appropriately. In this driving simulator investigation, 45 drivers experienced two FCW systems: a non-adaptive and an adaptive FCW that adjusted the timing of its alarms according to each individual driver’s reaction time. Whilst all drivers benefited in terms of improved safety from both FCW systems, non-aggressive drivers (low sensation seeking, long followers) did not display a preference to the adaptive FCW over its non-adaptive equivalent. Furthermore, there was little evidence to suggest that the non-aggressive drivers’ performance differed with either system. Benefits of the adaptive system were demonstrated for aggressive drivers (high sensation seeking, short followers). Even though both systems reduced their likelihood of a crash to a similar extent, the aggressive drivers rated each FCW more poorly than their non-aggressive contemporaries. However, this group, with their greater risk of involvement in rear-end collisions, reported a preference for the adaptive system as they found it less irritating and stress-inducing. Achieving greater acceptance and hence likely use of a real system is fundamental to good quality FCW design